Version 5.4
Mus musculus Gene: Slc6a2
Summary
InnateDB Gene IDBG-180391.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc6a2
Gene Name solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Synonyms NE-T; NET; Slc6a5
Species Mus musculus
Ensembl Gene ENSMUSG00000055368
Encoded Proteins
IDBP-180393
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
IDBP-621445
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103546:
This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:92960079-93001667
Strand Forward strand
Band C5
Transcripts
ENSMUST00000072939 ENSMUSP00000072709
ENSMUST00000165470 ENSMUSP00000129869
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005333 norepinephrine transmembrane transporter activity
GO:0005515 protein binding
GO:0008504 monoamine transmembrane transporter activity
GO:0043014 alpha-tubulin binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0006836 neurotransmitter transport
GO:0015844 monoamine transport
GO:0015874 norepinephrine transport
GO:0042493 response to drug
GO:0048265 response to pain
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0043005 neuron projection
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000103546
View Gene Order
ENSBTAG00000003353
Not yet available
Pathways
NETPATH
REACTOME
REACT_217615
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_253228
Na+/Cl- dependent neurotransmitter transporters pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20506
Na+/Cl- dependent neurotransmitter transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.489103 Mm.57040
RefSeq NM_009209 XM_006530793 XM_006530794
OMIM
CCDS CCDS22525
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca