Version 5.4
Mus musculus Gene: March8
Summary
InnateDB Gene IDBG-180544.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol March8
Gene Name membrane-associated ring finger (C3HC4) 8
Synonyms 1300017E09Rik; Mir
Species Mus musculus
Ensembl Gene ENSMUSG00000025702
Encoded Proteins
IDBP-180546
membrane-associated ring finger (C3HC4) 8
IDBP-180548
membrane-associated ring finger (C3HC4) 8
IDBP-538270
membrane-associated ring finger (C3HC4) 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165406:
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:116338024-116409540
Strand Forward strand
Band E3
Transcripts
ENSMUST00000079012 ENSMUSP00000078024
ENSMUST00000101032 ENSMUSP00000098594
ENSMUST00000127992
ENSMUST00000126376
ENSMUST00000140884
ENSMUST00000129170
ENSMUST00000130445
ENSMUST00000135901 ENSMUSP00000115510
ENSMUST00000123246
ENSMUST00000123405
ENSMUST00000156014
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042289 MHC class II protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II
GO:0016567 protein ubiquitination
GO:0045347 negative regulation of MHC class II biosynthetic process
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031901 early endosome membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165406
View Gene Order
ENSBTAG00000019537
Not yet available
Cross-References
SwissProt Q9DBD2
TrEMBL Q3U7P8
UniProt Splice Variant
Entrez Gene 71779
UniGene Mm.27064 Mm.410427 Mm.413661
RefSeq XM_006506646 XM_006506647 XM_006506648 NM_027920
OMIM
CCDS CCDS20451
HPRD
IMGT
MGI ID MGI:1919029
MGI Symbol March8
EMBL AK005032 AK152569 AK154976 BC050908 BC053090
GenPept AAH50908 AAH53090 BAB23759 BAE31321 BAE32966
RNA Seq Atlas 71779

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca