Version 5.4
Mus musculus Gene: Klf8
Summary
InnateDB Gene IDBG-180756.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klf8
Gene Name Kruppel-like factor 8
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041649
Encoded Proteins
IDBP-180758
Kruppel-like factor 8
IDBP-255724
Kruppel-like factor 8
IDBP-536360
Kruppel-like factor 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102349:
This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:153237466-153396132
Strand Forward strand
Band F3
Transcripts
ENSMUST00000039545 ENSMUSP00000044317
ENSMUST00000112574 ENSMUSP00000108193
ENSMUST00000143880 ENSMUSP00000117653
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102349
View Gene Order
ENSBTAG00000005852
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
fak_pathway
Signaling events mediated by focal adhesion kinase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 245671
UniGene Mm.260751 Mm.489131
RefSeq NM_173780 XM_006528852 XM_006528853 XM_006528854 XM_006528855 XM_006528856 XM_006528857 XM_006528858 XM_006528859 XM_006528860
OMIM
CCDS CCDS30481
HPRD
IMGT
MGI ID MGI:2442430
MGI Symbol Klf8
EMBL
GenPept
RNA Seq Atlas 245671

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca