Version 5.4
Homo sapiens Gene: GP2
Summary
InnateDB Gene IDBG-18165.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GP2
Gene Name glycoprotein 2 (zymogen granule membrane)
Synonyms ZAP75
Species Homo sapiens
Ensembl Gene ENSG00000169347
Encoded Proteins
IDBP-18167
glycoprotein 2 (zymogen granule membrane)
IDBP-18169
glycoprotein 2 (zymogen granule membrane)
IDBP-18171
glycoprotein 2 (zymogen granule membrane)
IDBP-18173
glycoprotein 2 (zymogen granule membrane)
IDBP-745851
IDBP-750952
IDBP-752030
IDBP-753685
IDBP-752500
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21468225
GP2 on M cells (specialized epithelial antigen-transporting cells) functions as an uptake receptor for a subset of commensal and pathogenic bacteria. GP2 interacts with type 1 pilus of gram-negative enterobacilli such as E. coli and Salmonella enterica. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21468225
[Mus musculus] Gp2 on M cells (specialized epithelial antigen-transporting cells) functions as an uptake receptor for a subset of commensal and pathogenic bacteria. Gp2 interacts with type 1 pilus of gram-negative enterobacilli such as E. coli and Salmonella enterica.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:20309572-20327808
Strand Reverse strand
Band p12.3
Transcripts
ENST00000381362 ENSP00000370767
ENST00000302555 ENSP00000304044
ENST00000341642 ENSP00000343861
ENST00000381360 ENSP00000370765
ENST00000572347 ENSP00000461632
ENST00000573897
ENST00000575730
ENST00000574982 ENSP00000460124
ENST00000575582 ENSP00000460466
ENST00000572478 ENSP00000461061
ENST00000575449 ENSP00000460059
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
Biological Process
GO:0002412 antigen transcytosis by M cells in mucosal-associated lymphoid tissue
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0016324 apical plasma membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030954
View Gene Order
ENSBTAG00000006263
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.53985
RefSeq NM_001007240 NM_001007241 NM_001007242 NM_001502 XM_005255259 XM_005255261
HUGO
OMIM
CCDS CCDS10582 CCDS42128 CCDS45432 CCDS45433
HPRD 04279
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca