Version 5.4
Homo sapiens Gene: USP46
Summary
InnateDB Gene IDBG-18223.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP46
Gene Name ubiquitin specific peptidase 46
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109189
Encoded Proteins
IDBP-367861
ubiquitin specific peptidase 46
IDBP-367863
ubiquitin specific peptidase 46
IDBP-483850
ubiquitin specific peptidase 46
IDBP-474266
ubiquitin specific peptidase 46
IDBP-477899
ubiquitin specific peptidase 46
IDBP-481152
ubiquitin specific peptidase 46
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:52590972-52659335
Strand Reverse strand
Band q12
Transcripts
ENST00000441222 ENSP00000407818
ENST00000451218 ENSP00000390102
ENST00000503060 ENSP00000422018
ENST00000514536 ENSP00000426970
ENST00000508499 ENSP00000423244
ENST00000502443
ENST00000506707
ENST00000512656 ENSP00000425806
ENST00000504078
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 23 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0001662 behavioral fear response
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008343 adult feeding behavior
GO:0016579 protein deubiquitination
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0048149 behavioral response to ethanol
GO:0060013 righting reflex
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054814
View Gene Order
ENSBTAG00000003443
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595781 Hs.706899 Hs.7966
RefSeq NM_001134223 NM_001286767 NM_001286768 NM_022832
HUGO
OMIM
CCDS CCDS47053 CCDS47054
HPRD 07507
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca