Version 5.4
Bos taurus Gene: USP46
Summary
InnateDB Gene IDBG-642232.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP46
Gene Name ubiquitin carboxyl-terminal hydrolase 46
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003443
Encoded Proteins
IDBP-694668
ubiquitin specific peptidase 46
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109189:
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:69952426-70003063
Strand Reverse strand
Band
Transcripts
ENSBTAT00000004472 ENSBTAP00000004472
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0001662 behavioral fear response
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008343 adult feeding behavior
GO:0016579 protein deubiquitination
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0048149 behavioral response to ethanol
GO:0060013 righting reflex
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000109189
View Gene Order
ENSMUSG00000054814
View Gene Order
Cross-References
SwissProt
TrEMBL F1MZM8
UniProt Splice Variant
Entrez Gene 516420
UniGene Bt.104421 Bt.25057
RefSeq NM_001192444 XM_005207957
HUGO HGNC:20075
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02017666 DAAA02017667
GenPept
RNA Seq Atlas 516420

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca