InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Agxt

Summary

InnateDB Gene

IDBG-182613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agxt

Gene Name

alanine-glyoxylate aminotransferase

Synonyms

AGT; Agt1; Agxt1; SPT

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026272

Encoded Proteins

IDBP-182615

alanine-glyoxylate aminotransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172482:
This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:93135240-93145421

Strand

Forward strand

Band

Transcripts

ENSMUST00000027491	ENSMUSP00000027491
ENSMUST00000191039
ENSMUST00000190603

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004760	serine-pyruvate transaminase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008453	alanine-glyoxylate transaminase activity
GO:0008483	transaminase activity
GO:0016597	amino acid binding
GO:0030170	pyridoxal phosphate binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006625	protein targeting to peroxisome
GO:0008152	metabolic process
GO:0009436	glyoxylate catabolic process
GO:0019265	glycine biosynthetic process, by transamination of glyoxylate
GO:0019448	L-cysteine catabolic process
GO:0042853	L-alanine catabolic process
GO:0042866	pyruvate biosynthetic process
GO:0046487	glyoxylate metabolic process
GO:0046724	oxalic acid secretion
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP