Version 5.4
Mus musculus Gene: Ano7
Summary
InnateDB Gene IDBG-183124.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ano7
Gene Name anoctamin 7
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000034107
Encoded Proteins
IDBP-183126
anoctamin 7
IDBP-790258
anoctamin 7
IDBP-790259
anoctamin 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. In humans, this protein is primarily found in prostate tissues and may serve as a target for prostate cancer immunotherapy. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:93373930-93404303
Strand Forward strand
Band D
Transcripts
ENSMUST00000058682 ENSMUSP00000050495
ENSMUST00000186641 ENSMUSP00000140438
ENSMUST00000190340 ENSMUSP00000139733
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005229 intracellular calcium activated chloride channel activity
GO:0017128 phospholipid scramblase activity
Biological Process
GO:0006821 chloride transport
GO:0061589 calcium activated phosphatidylserine scrambling
GO:0061590 calcium activated phosphatidylcholine scrambling
GO:0061591 calcium activated galactosylceramide scrambling
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000146205
View Gene Order
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_268398
Orphan transporters pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_267716
Orphan transporters pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q14AT5
TrEMBL
UniProt Splice Variant
Entrez Gene 404545
UniGene Mm.297411
RefSeq NM_001271884 NM_207031 XM_006529733 XM_006529734 XM_006529735 XM_006529737
OMIM
CCDS CCDS15188
HPRD
IMGT
MGI ID MGI:3052714
MGI Symbol Ano7
EMBL AC108412 AC124669 BC116706 BK004075
GenPept AAI16707 DAA04566
RNA Seq Atlas 404545

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca