InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ulk2

Summary

InnateDB Gene

IDBG-183710.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ulk2

Gene Name

unc-51 like kinase 2

Synonyms

A830085I22Rik; AU015340; mKIAA0623; Unc51.2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004798

Encoded Proteins

IDBP-183712

Unc-51 like kinase 2 (C. elegans)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000083290:
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:61775649-61855073

Strand

Reverse strand

Band

Transcripts

ENSMUST00000004920	ENSMUSP00000004920
ENSMUST00000129025
ENSMUST00000157049

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006468	protein phosphorylation
GO:0006914	autophagy
GO:0007165	signal transduction
GO:0007409	axonogenesis
GO:0009103	lipopolysaccharide biosynthetic process
GO:0010506	regulation of autophagy
GO:0042594	response to starvation
GO:0046777	protein autophosphorylation
GO:0048671	negative regulation of collateral sprouting
GO:0048675	axon extension

Cellular Component

GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0034045	pre-autophagosomal structure membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000083290

View Gene Order

ENSBTAG00000030977

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04140

Regulation of autophagy pathway

mmu04150

mTOR signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04150

mTOR signaling pathway pathway

hsa04140

Regulation of autophagy pathway

INOH

PID NCI

Cross-References

SwissProt

Q9QY01

TrEMBL

UniProt Splice Variant

Entrez Gene

29869

UniGene

Mm.162025 Mm.405782

RefSeq

NM_013881

OMIM

CCDS

CCDS24820

HPRD

IMGT

MGI ID

MGI:1352758

MGI Symbol

Ulk2

EMBL

AB019577 AF145922 AK122331 AK146620 BC046778 BC053029

GenPept

AAF18325 AAH46778 AAH53029 BAA77341 BAC65613 BAE27309

RNA Seq Atlas

29869