Version 5.4
| Mus musculus Gene: Fut2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-184002.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Fut2 | ||||||||
| Gene Name | fucosyltransferase 2 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000055978 | ||||||||
| Encoded Proteins |
fucosyltransferase 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is involved in the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene results in altered glycosylation of gastric mucosa and uterine epithelia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 7:45648595-45666308 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | B3 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Glycosphingolipid biosynthesis pathway
Glycosphingolipid biosynthesis pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Glycosphingolipid biosynthesis pathway
Glycosphingolipid biosynthesis pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9JL27 | ||||||||
| TrEMBL | A6H6C9 Q91VF0 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 14344 | ||||||||
| UniGene | Mm.290046 | ||||||||
| RefSeq | NM_001271993 NM_018876 XM_006540617 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS21258 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:109374 | ||||||||
| MGI Symbol | Fut2 | ||||||||
| EMBL | AB039114 AB039115 AB039116 AB039117 AB039118 AB039119 AB039120 AB039121 AF214656 AK033520 BC138534 BC145831 CH466603 | ||||||||
| GenPept | AAF45146 AAI38535 AAI45832 BAB68638 BAB68639 BAB68640 BAB68641 BAB68642 BAB68643 BAB68644 BAB68645 BAC28338 EDL22881 | ||||||||
| RNA Seq Atlas | 14344 | ||||||||