Version 5.4
Mus musculus Gene: Ap1s2
Summary
InnateDB Gene IDBG-184253.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ap1s2
Gene Name adaptor-related protein complex 1, sigma 2 subunit
Synonyms 1500012A13Rik; AI853648; EST1
Species Mus musculus
Ensembl Gene ENSMUSG00000031367
Encoded Proteins
IDBP-184255
adaptor-related protein complex 1, sigma 2 subunit
IDBP-184257
adaptor-related protein complex 1, sigma 2 subunit
IDBP-256317
adaptor-related protein complex 1, sigma 2 subunit
IDBP-537850
adaptor-related protein complex 1, sigma 2 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182287:
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:163909017-163933666
Strand Forward strand
Band F5
Transcripts
ENSMUST00000033734 ENSMUSP00000033734
ENSMUST00000069041 ENSMUSP00000066185
ENSMUST00000112294 ENSMUSP00000107913
ENSMUST00000140845 ENSMUSP00000114902
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008565 protein transporter activity
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005905 coated pit
GO:0030117 membrane coat
GO:0030659 cytoplasmic vesicle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000182287
View Gene Order
ENSBTAG00000020420
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_231722
Lysosome Vesicle Biogenesis pathway
REACT_230745
Immune System pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_11103
Nef mediated downregulation of MHC class I complex cell surface expression pathway
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6185
HIV Infection pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
REACT_219531
Golgi Associated Vesicle Biogenesis pathway
REACT_213138
Immune System pathway
REACT_216751
Clathrin derived vesicle budding pathway
REACT_211133
MHC class II antigen presentation pathway
REACT_211153
trans-Golgi Network Vesicle Budding pathway
REACT_214469
Adaptive Immune System pathway
REACT_205891
Lysosome Vesicle Biogenesis pathway
REACT_213260
Membrane Trafficking pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.397355 Mm.405489 Mm.426783 Mm.447762 Mm.490499
RefSeq NM_001290378 NM_001290379 NM_026887 XM_006528675 XM_006528676 XM_006528677
OMIM
CCDS CCDS30514 CCDS72465 CCDS72466
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca