Version 5.4
Homo sapiens Gene: AP1S2
Summary
InnateDB Gene IDBG-47029.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP1S2
Gene Name adaptor-related protein complex 1, sigma 2 subunit
Synonyms MGC:1902; MRX59; MRXS21; MRXS5; MRXSF; PGS; SIGMA1B
Species Homo sapiens
Ensembl Gene ENSG00000182287
Encoded Proteins
IDBP-47031
adaptor-related protein complex 1, sigma 2 subunit
IDBP-47035
adaptor-related protein complex 1, sigma 2 subunit
IDBP-362877
adaptor-related protein complex 1, sigma 2 subunit
IDBP-362886
adaptor-related protein complex 1, sigma 2 subunit
IDBP-586184
adaptor-related protein complex 1, sigma 2 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:15825806-15855014
Strand Reverse strand
Band p22.2
Transcripts
ENST00000329235 ENSP00000328789
ENST00000380291 ENSP00000369645
ENST00000452376 ENSP00000403498
ENST00000450644 ENSP00000389474
ENST00000479184
ENST00000545766 ENSP00000444957
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008565 protein transporter activity
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0050690 regulation of defense response to virus by virus
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005905 coated pit
GO:0030117 membrane coat
GO:0030119 AP-type membrane coat adaptor complex
GO:0030659 cytoplasmic vesicle membrane
GO:0032588 trans-Golgi network membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031367
View Gene Order
ENSBTAG00000020420
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_11103
Nef mediated downregulation of MHC class I complex cell surface expression pathway
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6185
HIV Infection pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 8905
UniGene Hs.121592
RefSeq NM_001272071 NM_003916 XM_005274612
HUGO HGNC:560
OMIM 300629
CCDS CCDS75958 CCDS14173
HPRD 04636
IMGT
EMBL
GenPept
RNA Seq Atlas 8905

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca