Mus musculus Gene: Onecut1
Summary
InnateDB Gene IDBG-184608.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Onecut1
Gene Name one cut domain, family member 1
Synonyms D9Ertd423e; Hfh12; HNF-6; Hnf6; Hnf6b; OC-1; Oc1
Species Mus musculus
Ensembl Gene ENSMUSG00000043013
Encoded Proteins
one cut domain, family member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169856:
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:74861921-74891781
Strand Forward strand
Band D
Transcripts
ENSMUST00000056006 ENSMUSP00000058020
ENSMUST00000160499
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 222 interaction(s) predicted by orthology.
Predicted by orthology
Total 222 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001889 liver development
GO:0001952 regulation of cell-matrix adhesion
GO:0002064 epithelial cell development
GO:0006006 glucose metabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007492 endoderm development
GO:0009653 anatomical structure morphogenesis
GO:0030154 cell differentiation
GO:0030183 B cell differentiation
GO:0030335 positive regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031016 pancreas development
GO:0031018 endocrine pancreas development
GO:0042384 cilium assembly
GO:0045165 cell fate commitment
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048536 spleen development
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Regulation of gene expression in early pancreatic precursor cells pathway
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells pathway
Developmental Biology pathway
Regulation of beta-cell development pathway
KEGG
Maturity onset diabetes of the young pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells pathway
Regulation of gene expression in early pancreatic precursor cells pathway
Developmental Biology pathway
Regulation of beta-cell development pathway
KEGG
Maturity onset diabetes of the young pathway
INOH
PID NCI
FOXM1 transcription factor network
Cross-References
SwissProt O08755
TrEMBL Q2M4H1
UniProt Splice Variant
Entrez Gene 15379
UniGene Mm.303355 Mm.484074
RefSeq NM_008262
OMIM
CCDS CCDS23339
HPRD
IMGT
MGI ID MGI:1196423
MGI Symbol Onecut1
EMBL AY902344 BC024053 U95945
GenPept AAB53863 AAH24053 AAY21054
RNA Seq Atlas 15379