InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.37181

Summary

InnateDB Gene

IDBG-646644.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.37181

Gene Name

hepatocyte nuclear factor 6

Synonyms

HNF-6a

Species

Bos taurus

Ensembl Gene

ENSBTAG00000046470

Encoded Proteins

IDBP-699465

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169856:
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:57712108-57744837

Strand

Forward strand

Band

Transcripts

ENSBTAT00000066281

ENSBTAP00000055953

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 210 interaction(s) predicted by orthology.

Predicted by orthology
Total	210 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001889	liver development
GO:0001952	regulation of cell-matrix adhesion
GO:0002064	epithelial cell development
GO:0006006	glucose metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007492	endoderm development
GO:0009653	anatomical structure morphogenesis
GO:0030154	cell differentiation
GO:0030183	B cell differentiation
GO:0030335	positive regulation of cell migration
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031016	pancreas development
GO:0031018	endocrine pancreas development
GO:0042384	cilium assembly
GO:0045165	cell fate commitment
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048536	spleen development