InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Clp1

Summary

InnateDB Gene

IDBG-185205.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clp1

Gene Name

CLP1, cleavage and polyadenylation factor I subunit

Synonyms

AI462438; Heab

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027079

Encoded Proteins

IDBP-185207

CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)

IDBP-623979

CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172409:
This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:84722104-84727350

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028475	ENSMUSP00000028475
ENSMUST00000138231
ENSMUST00000165219	ENSMUSP00000129300

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
GO:0051733	polydeoxyribonucleotide kinase activity
GO:0051736	ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity

Biological Process

GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation
GO:0008219	cell death
GO:0016310	phosphorylation
GO:0021695	cerebellar cortex development
GO:0030423	targeting of mRNA for destruction involved in RNA interference
GO:0031124	mRNA 3'-end processing
GO:0035087	siRNA loading onto RISC involved in RNA interference