Version 5.4
Mus musculus Gene: Elac2
Summary
InnateDB Gene IDBG-185767.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Elac2
Gene Name elaC homolog 2 (E. coli)
Synonyms 1110017O07Rik; D11Wsu80e; Hpc2
Species Mus musculus
Ensembl Gene ENSMUSG00000020549
Encoded Proteins
IDBP-185769
elaC homolog 2 (E. coli)
IDBP-185771
elaC homolog 2 (E. coli)
IDBP-263986
elaC homolog 2 (E. coli)
IDBP-541956
elaC homolog 2 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006744:
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64979038-65002069
Strand Forward strand
Band B3
Transcripts
ENSMUST00000101049 ENSMUSP00000098610
ENSMUST00000071891 ENSMUSP00000071788
ENSMUST00000108697 ENSMUSP00000104337
ENSMUST00000142574
ENSMUST00000140369
ENSMUST00000132308 ENSMUSP00000117422
ENSMUST00000128693
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004519 endonuclease activity
GO:0016787 hydrolase activity
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0008033 tRNA processing
GO:0008152 metabolic process
GO:0072684 mitochondrial tRNA 3'-trailer cleavage, endonucleolytic
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000006744
View Gene Order
ENSBTAG00000021939
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03013
RNA transport pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.157711
RefSeq NM_023479 XM_006534065 XM_006534066 XM_006534067 XM_006534068
OMIM
CCDS CCDS24841
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca