Version 5.4
Bos taurus Gene: ELAC2
Summary
InnateDB Gene IDBG-637320.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELAC2
Gene Name zinc phosphodiesterase ELAC protein 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021939
Encoded Proteins
IDBP-689328
elaC homolog 2 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006744:
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:31965968-31982771
Strand Reverse strand
Band
Transcripts
ENSBTAT00000029249 ENSBTAP00000029249
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008033 tRNA processing
GO:0072684 mitochondrial tRNA 3'-trailer cleavage, endonucleolytic
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000006744
View Gene Order
ENSMUSG00000020549
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
mmu03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BDK7
UniProt Splice Variant
Entrez Gene 509256
UniGene Bt.3261
RefSeq NM_001193065
HUGO HGNC:14198
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02048902 DAAA02048903 DAAA02048904
GenPept
RNA Seq Atlas 509256

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca