Version 5.4
Homo sapiens Gene: ELAC2
Summary
InnateDB Gene IDBG-31246.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELAC2
Gene Name elaC homolog 2 (E. coli)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000006744
Encoded Proteins
IDBP-31248
elaC homolog 2 (E. coli)
IDBP-238460
elaC homolog 2 (E. coli)
IDBP-369318
elaC homolog 2 (E. coli)
IDBP-369329
elaC homolog 2 (E. coli)
IDBP-759980
IDBP-762603
IDBP-758471
IDBP-759805
IDBP-811494
elaC ribonuclease Z 2
IDBP-760479
IDBP-811491
elaC ribonuclease Z 2
IDBP-811492
elaC ribonuclease Z 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:12992391-13018187
Strand Reverse strand
Band p12
Transcripts
ENST00000338034 ENSP00000337445
ENST00000395962 ENSP00000379291
ENST00000426905 ENSP00000405223
ENST00000446899 ENSP00000406192
ENST00000484122
ENST00000480891
ENST00000487229
ENST00000465825
ENST00000491478
ENST00000492559
ENST00000476042 ENSP00000463884
ENST00000578991
ENST00000580504 ENSP00000463594
ENST00000583371 ENSP00000464358
ENST00000584650 ENSP00000463740
ENST00000578071 ENSP00000477482
ENST00000581499 ENSP00000463321
ENST00000578104
ENST00000609345
ENST00000609101 ENSP00000477044
ENST00000609757 ENSP00000477093
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004519 endonuclease activity
GO:0016787 hydrolase activity
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0008033 tRNA processing
GO:0008152 metabolic process
GO:0072684 mitochondrial tRNA 3'-trailer cleavage, endonucleolytic
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020549
View Gene Order
ENSBTAG00000021939
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.434232
RefSeq NM_001165962 NM_018127 NM_173717
HUGO
OMIM
CCDS CCDS11164 CCDS54093
HPRD 05641
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca