Version 5.4
Mus musculus Gene: Serpinb7
Summary
InnateDB Gene IDBG-186302.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serpinb7
Gene Name serine (or cysteine) peptidase inhibitor, clade B, member 7
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000067001
Encoded Proteins
IDBP-186304
serine (or cysteine) peptidase inhibitor, clade B, member 7
IDBP-532254
serine (or cysteine) peptidase inhibitor, clade B, member 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166396:
This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:107399655-107452689
Strand Forward strand
Band E2.1
Transcripts
ENSMUST00000086690 ENSMUSP00000083896
ENSMUST00000154538 ENSMUSP00000119217
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
GO:0032914 positive regulation of transforming growth factor beta1 production
GO:0032967 positive regulation of collagen biosynthetic process
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:0090362 positive regulation of platelet-derived growth factor production
Cellular Component
GO:0005575 cellular_component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166396
View Gene Order
ENSBTAG00000037773
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.66015
RefSeq NM_027548 XM_006529086 XM_006529087
OMIM
CCDS CCDS35686
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca