InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Celsr2

Summary

InnateDB Gene

IDBG-187099.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Celsr2

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)

Synonyms

EGFL2; flamingo; Flamingo1; mfmi1; mKIAA0279

Species

Mus musculus

Ensembl Gene

ENSMUSG00000068740

Encoded Proteins

IDBP-187103

cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)

IDBP-539441

cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)

IDBP-541982

cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143126:
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:108390851-108415552

Strand

Reverse strand

Band

Transcripts

ENSMUST00000090558	ENSMUSP00000088046
ENSMUST00000147251	ENSMUSP00000122329
ENSMUST00000133216
ENSMUST00000126935
ENSMUST00000130941
ENSMUST00000126349
ENSMUST00000147565	ENSMUSP00000122516

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0003341	cilium movement
GO:0007156	homophilic cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0021591	ventricular system development
GO:0032880	regulation of protein localization
GO:0033326	cerebrospinal fluid secretion
GO:0042384	cilium assembly

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000143126

View Gene Order

ENSBTAG00000018804

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.39728 Mm.407867 Mm.408258 Mm.418618

RefSeq

NM_001004177 NM_017392 XM_006501692

OMIM

CCDS

CCDS17759

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas