Version 5.4
Mus musculus Gene: Rspo1
Summary
InnateDB Gene IDBG-187261.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rspo1
Gene Name R-spondin homolog (Xenopus laevis)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000028871
Encoded Proteins
IDBP-187263
R-spondin homolog (Xenopus laevis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169218:
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:124986430-125009099
Strand Forward strand
Band D2.2
Transcripts
ENSMUST00000030687 ENSMUSP00000030687
ENSMUST00000140698
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008201 heparin binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002090 regulation of receptor internalization
GO:0007140 male meiosis
GO:0010468 regulation of gene expression
GO:0030177 positive regulation of Wnt signaling pathway
GO:0060070 canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2000052 positive regulation of non-canonical Wnt signaling pathway
GO:2000254 regulation of male germ cell proliferation
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169218
View Gene Order
ENSBTAG00000003837
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_8
Wnt pathway
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200716
regulation of FZD by ubiquitination pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
wnt_signaling_pathway
Wnt signaling network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.403751 Mm.42202
RefSeq NM_138683
OMIM
CCDS CCDS18633
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca