InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.27743

Summary

InnateDB Gene

IDBG-641175.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.27743

Gene Name

R-spondin-1 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003837

Encoded Proteins

IDBP-693506

R-spondin-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169218:
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:108854245-108874912

Strand

Forward strand

Band

Transcripts

ENSBTAT00000005002

ENSBTAP00000005002

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008201	heparin binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0002090	regulation of receptor internalization
GO:0007140	male meiosis
GO:0010468	regulation of gene expression
GO:0030177	positive regulation of Wnt signaling pathway
GO:0060070	canonical Wnt signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2000052	positive regulation of non-canonical Wnt signaling pathway
GO:2000254	regulation of male germ cell proliferation