Version 5.4
Mus musculus Gene: Krt18
Summary
InnateDB Gene IDBG-187416.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Krt18
Gene Name keratin 18
Synonyms CK18; K18; Krt1-18
Species Mus musculus
Ensembl Gene ENSMUSG00000023043
Encoded Proteins
IDBP-187418
keratin 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111057:
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:102028216-102032026
Strand Forward strand
Band F2
Transcripts
ENSMUST00000023803 ENSMUSP00000023803
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 77 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0097110 scaffold protein binding
Biological Process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0043000 Golgi to plasma membrane CFTR protein transport
GO:0043066 negative regulation of apoptotic process
GO:0045104 intermediate filament cytoskeleton organization
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097284 hepatocyte apoptotic process
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005882 intermediate filament
GO:0016363 nuclear matrix
GO:0034451 centriolar satellite
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000111057
View Gene Order
ENSBTAG00000001517
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
Cross-References
SwissProt P05784
TrEMBL
UniProt Splice Variant
Entrez Gene 16668
UniGene Mm.22479
RefSeq NM_010664 XM_006520512 XM_006520513
OMIM
CCDS CCDS27869
HPRD
IMGT
MGI ID MGI:96692
MGI Symbol Krt18
EMBL AK145413 AK167072 AK167265 AK167432 AK167469 AK167676 BC089022 M11686 M22832 M36376 Y00217
GenPept AAA37552 AAA39373 AAA39390 AAH89022 BAE26424 BAE39232 BAE39378 BAE39519 BAE39553 BAE39725 CAA68365
RNA Seq Atlas 16668

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca