Version 5.4
Bos taurus Gene: KRT18
Summary
InnateDB Gene IDBG-631626.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT18
Gene Name keratin, type I cytoskeletal 18
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001517
Encoded Proteins
IDBP-683170
KRT18 proteinUncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111057:
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:27171925-27175575
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001988 ENSBTAP00000001988
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.
Predicted by orthology
Total 65 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0097110 scaffold protein binding
Biological Process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0043000 Golgi to plasma membrane CFTR protein transport
GO:0043066 negative regulation of apoptotic process
GO:0045104 intermediate filament cytoskeleton organization
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097284 hepatocyte apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005882 intermediate filament
GO:0034451 centriolar satellite
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000111057
View Gene Order
ENSMUSG00000023043
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
Cross-References
SwissProt
TrEMBL A1XEA4 A1XEA5 A6H7D3 F6S1Q0
UniProt Splice Variant
Entrez Gene 506480
UniGene Bt.65129
RefSeq NM_001192095
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146203 DAAA02012876 DQ347569 DQ347570
GenPept AAI46204 ABC55278 ABC55279
RNA Seq Atlas 506480

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca