Version 5.4
Mus musculus Gene: Eif4b
Summary
InnateDB Gene IDBG-187457.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif4b
Gene Name eukaryotic translation initiation factor 4B
Synonyms 2310046H11Rik; AL024095; C85189; Eif4a2
Species Mus musculus
Ensembl Gene ENSMUSG00000058655
Encoded Proteins
IDBP-625652
eukaryotic translation initiation factor 4B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000063046:
Gene Information
Type Protein coding
Genomic Location Chromosome 15:102073773-102097172
Strand Forward strand
Band F2
Transcripts
ENSMUST00000169681 ENSMUSP00000127774
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000063046
View Gene Order
ENSBTAG00000006883
Not yet available
Pathways
NETPATH
REACTOME
REACT_240250
Signaling by Insulin receptor pathway
REACT_255163
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_229737
S6K1 signalling pathway
REACT_244119
Deadenylation of mRNA pathway
REACT_254308
Translation pathway
REACT_256488
Translation initiation complex formation pathway
REACT_247926
Metabolism of proteins pathway
REACT_229570
Cap-dependent Translation Initiation pathway
REACT_262064
Eukaryotic Translation Initiation pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_260675
S6K1-mediated signalling pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_240139
PI3K Cascade pathway
REACT_233572
Gene Expression pathway
REACT_243154
IRS-related events pathway
REACT_242206
IRS-mediated signalling pathway
REACT_231630
mTORC1-mediated signalling pathway
REACT_259469
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_188257
Signal Transduction pathway
REACT_236458
Ribosomal scanning and start codon recognition pathway
REACT_255725
mTOR signalling pathway
REACT_256714
PKB-mediated events pathway
REACT_262078
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_235784
Deadenylation-dependent mRNA decay pathway
KEGG
mmu04150
mTOR signaling pathway pathway
mmu03013
RNA transport pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_6772
S6K1 signalling pathway
REACT_6754
S6K1-mediated signalling pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_20514
Deadenylation of mRNA pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_456
PKB-mediated events pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_6964
mTORC1-mediated signalling pathway
REACT_1014
Translation pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_17015
Metabolism of proteins pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_71
Gene Expression pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa03013
RNA transport pathway
INOH
PID NCI
mtor_4pathway
mTOR signaling pathway
Cross-References
SwissProt Q8BGD9
TrEMBL B2RWE8 Q922K6
UniProt Splice Variant
Entrez Gene 75705
UniGene Mm.290022 Mm.418391 Mm.427880
RefSeq NM_145625
OMIM
CCDS CCDS49737
HPRD
IMGT
MGI ID MGI:95304
MGI Symbol Eif4b
EMBL AK045250 AK077423 AK170354 BC007171 BC147746 BC147748
GenPept AAH07171 AAI47747 AAI47749 BAC32280 BAC36793 BAE41740
RNA Seq Atlas 75705

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca