InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cul7

Summary

InnateDB Gene

IDBG-187621.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cul7

Gene Name

cullin 7

Synonyms

2510004L20Rik; AA409809; C230011P08Rik; p185; p193

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038545

Encoded Proteins

IDBP-187623

cullin 7

IDBP-539665

cullin 7

IDBP-532116

cullin 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000044090:
The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:46650337-46664364

Strand

Forward strand

Band

Transcripts

ENSMUST00000043464	ENSMUSP00000049128
ENSMUST00000151002
ENSMUST00000132790
ENSMUST00000145567	ENSMUSP00000116133
ENSMUST00000144966
ENSMUST00000133393	ENSMUSP00000119393
ENSMUST00000125949

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0000281	mitotic cytokinesis
GO:0001570	vasculogenesis
GO:0001837	epithelial to mesenchymal transition
GO:0001890	placenta development
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006915	apoptotic process
GO:0007030	Golgi organization
GO:0007088	regulation of mitosis
GO:0016567	protein ubiquitination
GO:0042981	regulation of apoptotic process
GO:0045601	regulation of endothelial cell differentiation
GO:0050775	positive regulation of dendrite morphogenesis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0031461	cullin-RING ubiquitin ligase complex
GO:0031467	Cul7-RING ubiquitin ligase complex
GO:0048471	perinuclear region of cytoplasm
GO:1990393	3M complex