InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: E2f8

Summary

InnateDB Gene

IDBG-187710.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2f8

Gene Name

E2F transcription factor 8

Synonyms

4432406C08Rik; AA410048

Species

Mus musculus

Ensembl Gene

ENSMUSG00000046179

Encoded Proteins

IDBP-187714

E2F transcription factor 8

IDBP-400656

E2F transcription factor 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129173:
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:48866429-48881596

Strand

Reverse strand

Band

Transcripts

ENSMUST00000058745	ENSMUSP00000056778
ENSMUST00000119223	ENSMUSP00000112883
ENSMUST00000151139
ENSMUST00000136142

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001890	placenta development
GO:0002040	sprouting angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008283	cell proliferation
GO:0032466	negative regulation of cytokinesis
GO:0032877	positive regulation of DNA endoreduplication
GO:0033301	cell cycle comprising mitosis without cytokinesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060707	trophoblast giant cell differentiation
GO:0060718	chorionic trophoblast cell differentiation
GO:0070365	hepatocyte differentiation

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000129173

View Gene Order

ENSBTAG00000017446

Not yet available

Cross-References

SwissProt

Q58FA4

TrEMBL

UniProt Splice Variant

Entrez Gene

108961

UniGene

Mm.240566 Mm.406145

RefSeq

NM_001013368 XM_006540554 XM_006540553

OMIM

CCDS

CCDS39967

HPRD

IMGT

MGI ID

MGI:1922038

MGI Symbol

E2f8

EMBL

AK049525 AK084513 AK154018 AK157235 AK160240 AY957576 BC086675 BC100357

GenPept

AAH86675 AAI00358 AAX49603 BAC33794 BAC39205 BAE32318 BAE34010 BAE35708

RNA Seq Atlas

108961