Version 5.4
Homo sapiens Gene: MYH8
Summary
InnateDB Gene IDBG-30176.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYH8
Gene Name myosin, heavy chain 8, skeletal muscle, perinatal
Synonyms gtMHC-F; MyHC-peri; MyHC-pn
Species Homo sapiens
Ensembl Gene ENSG00000133020
Encoded Proteins
IDBP-294273
myosin, heavy chain 8, skeletal muscle, perinatal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is predominantly expressed in fetal skeletal muscle. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:10390322-10421950
Strand Reverse strand
Band p13.1
Transcripts
ENST00000403437 ENSP00000384330
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000146 microfilament motor activity
GO:0003774 motor activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008307 structural constituent of muscle
GO:0016887 ATPase activity
GO:0032027 myosin light chain binding
GO:0051015 actin filament binding
Biological Process
GO:0003009 skeletal muscle contraction
GO:0006200 ATP catabolic process
GO:0006936 muscle contraction
GO:0016192 vesicle-mediated transport
GO:0030049 muscle filament sliding
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005859 muscle myosin complex
GO:0016020 membrane
GO:0016459 myosin complex
GO:0030017 sarcomere
GO:0032982 myosin filament
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055775
View Gene Order
ENSBTAG00000009702
Not yet available
Pathways
NETPATH
REACTOME
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt P13535
TrEMBL
UniProt Splice Variant
Entrez Gene 4626
UniGene Hs.700484
RefSeq NM_002472
HUGO HGNC:7578
OMIM 160741
CCDS CCDS11153
HPRD
IMGT
EMBL AF067143 M36769 X51592 Z38133
GenPept AAC17185 AAC21557 CAA35941 CAA86293
RNA Seq Atlas 4626

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca