Version 5.4
Homo sapiens Gene: SP7
Summary
InnateDB Gene IDBG-36582.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SP7
Gene Name Sp7 transcription factor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170374
Encoded Proteins
IDBP-36584
Sp7 transcription factor
IDBP-597420
Sp7 transcription factor
IDBP-597294
Sp7 transcription factor
IDBP-592423
Sp7 transcription factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:53326575-53345315
Strand Reverse strand
Band q13.13
Transcripts
ENST00000303846 ENSP00000302812
ENST00000536324 ENSP00000443827
ENST00000537210 ENSP00000441367
ENST00000547755 ENSP00000449355
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0017151 DEAD/H-box RNA helicase binding
GO:0046872 metal ion binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060218 hematopoietic stem cell differentiation
GO:2000738 positive regulation of stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060284
View Gene Order
ENSBTAG00000033292
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.209402
RefSeq NM_001173467 NM_001300837 NM_152860 XM_005268643
HUGO
OMIM
CCDS CCDS44897 CCDS73475
HPRD 05971
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca