Version 5.4
Mus musculus Gene: Ccnd3
Summary
InnateDB Gene IDBG-189288.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccnd3
Gene Name cyclin D3
Synonyms 9230106B05Rik; AA682053; AL024085; AW146355; C78795
Species Mus musculus
Ensembl Gene ENSMUSG00000034165
Encoded Proteins
IDBP-189290
cyclin D3
IDBP-625012
cyclin D3
IDBP-789066
cyclin D3
IDBP-789067
cyclin D3
IDBP-789068
cyclin D3
IDBP-789069
cyclin D3
IDBP-789071
cyclin D3
IDBP-789072
cyclin D3
IDBP-789073
cyclin D3
IDBP-789075
cyclin D3
IDBP-789076
cyclin D3
IDBP-789077
cyclin D3
IDBP-789078
cyclin D3
IDBP-789080
cyclin D3
IDBP-789081
cyclin D3
IDBP-789082
cyclin D3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112576:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:47505051-47599691
Strand Forward strand
Band C
Transcripts
ENSMUST00000037333 ENSMUSP00000040488
ENSMUST00000171031 ENSMUSP00000126141
ENSMUST00000182129 ENSMUSP00000138486
ENSMUST00000183210 ENSMUSP00000138658
ENSMUST00000183044 ENSMUSP00000138220
ENSMUST00000183177 ENSMUSP00000138640
ENSMUST00000182848 ENSMUSP00000138715
ENSMUST00000182591
ENSMUST00000182060
ENSMUST00000182935 ENSMUSP00000138273
ENSMUST00000183014
ENSMUST00000183061
ENSMUST00000182506 ENSMUSP00000138180
ENSMUST00000182281
ENSMUST00000182209 ENSMUSP00000138091
ENSMUST00000182874 ENSMUSP00000138711
ENSMUST00000183158 ENSMUSP00000138169
ENSMUST00000182846 ENSMUSP00000138334
ENSMUST00000182539 ENSMUSP00000138458
ENSMUST00000183256 ENSMUSP00000138528
ENSMUST00000183206 ENSMUSP00000138745
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001934 positive regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0042098 T cell proliferation
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301 cell division
GO:0051726 regulation of cell cycle
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112576
View Gene Order
ENSBTAG00000010106
Not yet available
Pathways
NETPATH
REACTOME
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_188576
Developmental Biology pathway
KEGG
mmu04630
Jak-STAT signaling pathway pathway
mmu04115
p53 signaling pathway pathway
mmu04310
Wnt signaling pathway pathway
mmu04110
Cell cycle pathway
mmu04510
Focal adhesion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_12
BCR pathway
NetPath_23
TSH pathway
REACTOME
REACT_821
Cyclin D associated events in G1 pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_1590
G1 Phase pathway
REACT_111045
Developmental Biology pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_115566
Cell Cycle pathway
REACT_152
Cell Cycle, Mitotic pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04110
Cell cycle pathway
hsa04510
Focal adhesion pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
e2f_pathway
E2F transcription factor network
il2_stat5pathway
IL2 signaling events mediated by STAT5
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001081635 NM_001081636 NM_007632 XM_006523552 XM_006523553
OMIM
CCDS CCDS28850
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca