InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.29057

Summary

InnateDB Gene

IDBG-631016.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.29057

Gene Name

G1/S-specific cyclin-D3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010106

Encoded Proteins

IDBP-682508

G1/S-specific cyclin-D3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112576:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:15707556-15714372

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000036029

ENSBTAP00000035894

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0042098	T cell proliferation
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301	cell division
GO:0051726	regulation of cell cycle