Mus musculus Gene: Pole | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-189655.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Pole | ||||||||||||||||||||||
Gene Name | polymerase (DNA directed), epsilon | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000007080 | ||||||||||||||||||||||
Encoded Proteins |
polymerase (DNA directed), epsilon
polymerase (DNA directed), epsilon
polymerase (DNA directed), epsilon
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177084:
This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:110286306-110337474 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | F | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Transcription-coupled NER (TC-NER) pathway
Cell Cycle, Mitotic pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Chromosome Maintenance pathway
Synthesis of DNA pathway
Telomere C-strand synthesis initiation pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
DNA Replication pathway
Global Genomic NER (GG-NER) pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Telomere Maintenance pathway
Cell Cycle pathway
Nucleotide Excision Repair pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
DNA Repair pathway
Activation of the pre-replicative complex pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
M/G1 Transition pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
Extension of Telomeres pathway
DNA replication initiation pathway
DNA Replication Pre-Initiation pathway
S Phase pathway
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KEGG |
Pyrimidine metabolism pathway
DNA replication pathway
Purine metabolism pathway
Nucleotide excision repair pathway
Base excision repair pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Telomere C-strand synthesis initiation pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
DNA replication initiation pathway
Activation of the pre-replicative complex pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Transcription-coupled NER (TC-NER) pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
Chromosome Maintenance pathway
DNA Replication Pre-Initiation pathway
Global Genomic NER (GG-NER) pathway
Telomere Maintenance pathway
G1/S Transition pathway
Cell Cycle pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
Extension of Telomeres pathway
Nucleotide Excision Repair pathway
DNA Repair pathway
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KEGG |
Pyrimidine metabolism pathway
DNA replication pathway
Purine metabolism pathway
Nucleotide excision repair pathway
Base excision repair pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.35061 | ||||||||||||||||||||||
RefSeq | NM_011132 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS19525 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||