Version 5.4
Bos taurus Gene: BT.65618
Summary
InnateDB Gene IDBG-630895.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.65618
Gene Name DNA polymerase epsilon catalytic subunit A
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000590
Encoded Proteins
IDBP-682518
DNA polymerase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177084:
This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:45511664-45571259
Strand Forward strand
Band
Transcripts
ENSBTAT00000009882 ENSBTAP00000009882
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000731 DNA synthesis involved in DNA repair
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006287 base-excision repair, gap-filling
GO:0006297 nucleotide-excision repair, DNA gap filling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0008622 epsilon DNA polymerase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000177084
View Gene Order
ENSMUSG00000007080
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_7993
Telomere C-strand synthesis initiation pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_2244
DNA replication initiation pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_1993
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_74
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_378
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_1998
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_7970
Telomere Maintenance pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_8030
Extension of Telomeres pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_216
DNA Repair pathway
REACT_213655
Transcription-coupled NER (TC-NER) pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_202316
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_233453
Chromosome Maintenance pathway
REACT_258062
Synthesis of DNA pathway
REACT_224446
Telomere C-strand synthesis initiation pathway
REACT_219381
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_232628
DNA Replication pathway
REACT_238177
Global Genomic NER (GG-NER) pathway
REACT_237585
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_252672
Telomere Maintenance pathway
REACT_188804
Cell Cycle pathway
REACT_235422
Nucleotide Excision Repair pathway
REACT_209299
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_233397
DNA Repair pathway
REACT_254983
Activation of the pre-replicative complex pathway
REACT_220175
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_245528
M/G1 Transition pathway
REACT_253002
G1/S Transition pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_252545
Extension of Telomeres pathway
REACT_238214
DNA replication initiation pathway
REACT_235483
DNA Replication Pre-Initiation pathway
REACT_253623
S Phase pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa03030
DNA replication pathway
hsa00230
Purine metabolism pathway
hsa03420
Nucleotide excision repair pathway
hsa03410
Base excision repair pathway
mmu00240
Pyrimidine metabolism pathway
mmu03030
DNA replication pathway
mmu00230
Purine metabolism pathway
mmu03420
Nucleotide excision repair pathway
mmu03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BIF0
UniProt Splice Variant
Entrez Gene 785457
UniGene Bt.65618
RefSeq NM_001191429 XM_005217684 XM_005217685
HUGO HGNC:9177
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02044945 DAAA02044946
GenPept
RNA Seq Atlas 785457

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca