Version 5.4
Homo sapiens Gene: BDKRB1
Summary
InnateDB Gene IDBG-19028.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BDKRB1
Gene Name bradykinin receptor B1
Synonyms B1BKR; B1R; BDKRB2; BKB1R; BKR1; BRADYB1
Species Homo sapiens
Ensembl Gene ENSG00000100739
Encoded Proteins
IDBP-19030
bradykinin receptor B1
IDBP-587200
bradykinin receptor B1
IDBP-809785
bradykinin receptor B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:96255824-96268967
Strand Forward strand
Band q32.2
Transcripts
ENST00000216629 ENSP00000216629
ENST00000553356 ENSP00000452064
ENST00000557122
ENST00000611804 ENSP00000479276
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004947 bradykinin receptor activity
GO:0005515 protein binding
GO:0042277 peptide binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0002687 positive regulation of leukocyte migration
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0009612 response to mechanical stimulus
GO:0016477 cell migration
GO:0019233 sensory perception of pain
GO:0030308 negative regulation of cell growth
GO:0032496 response to lipopolysaccharide
GO:0045776 negative regulation of blood pressure
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041347
View Gene Order
ENSBTAG00000007052
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04610
Complement and coagulation cascades pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P46663
TrEMBL G3V4Y2
UniProt Splice Variant
Entrez Gene 623
UniGene Hs.525572
RefSeq NM_000710
HUGO HGNC:1029
OMIM 600337
CCDS CCDS9943
HPRD
IMGT
EMBL AB065896 AJ238044 AK291970 AL355102 AY275464 BC034705 CH471061 U12512 U22346 U48231
GenPept AAA21346 AAB60693 AAC50594 AAH34705 AAP32296 BAC06112 BAF84659 CAB45650 EAW81632
RNA Seq Atlas 623

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca