Version 5.4
Bos taurus Gene: BT.62541
Summary
InnateDB Gene IDBG-634180.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.62541
Gene Name B1 bradykinin receptor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007052
Encoded Proteins
IDBP-685939
B1 bradykinin receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100739:
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:62760703-62772148
Strand Forward strand
Band
Transcripts
ENSBTAT00000009271 ENSBTAP00000009271
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004947 bradykinin receptor activity
GO:0005515 protein binding
GO:0042277 peptide binding
Biological Process
GO:0006950 response to stress
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0009612 response to mechanical stimulus
GO:0032496 response to lipopolysaccharide
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100739
View Gene Order
ENSMUSG00000041347
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04610
Complement and coagulation cascades pathway
hsa04020
Calcium signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04610
Complement and coagulation cascades pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N0Q8
UniProt Splice Variant
Entrez Gene 532119
UniGene Bt.62541
RefSeq NM_001109999 XM_005222219
HUGO HGNC:1029
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02053159
GenPept
RNA Seq Atlas 532119

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca