Version 5.4
Mus musculus Gene: Nqo1
Summary
InnateDB Gene IDBG-190808.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nqo1
Gene Name NAD(P)H dehydrogenase, quinone 1
Synonyms AV001255; Dia4; Dtd; Nmo-1; Nmo1; Nmor1; Ox-1; Ox1; Qr1
Species Mus musculus
Ensembl Gene ENSMUSG00000003849
Encoded Proteins
IDBP-190810
NAD(P)H dehydrogenase, quinone 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181019:
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein\'s enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer\'s disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:107388225-107403206
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000003947 ENSMUSP00000003947
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003955 NAD(P)H dehydrogenase (quinone) activity
GO:0004784 superoxide dismutase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006801 superoxide metabolic process
GO:0006979 response to oxidative stress
GO:0007568 aging
GO:0007584 response to nutrient
GO:0014070 response to organic cyclic compound
GO:0019430 removal of superoxide radicals
GO:0032355 response to estradiol
GO:0043086 negative regulation of catalytic activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0045471 response to ethanol
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000181019
View Gene Order
ENSBTAG00000020632
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_234963
Regulation of ornithine decarboxylase (ODC) pathway
KEGG
mmu00130
Ubiquinone and other terpenoid-quinone biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13565
Regulation of ornithine decarboxylase (ODC) pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00130
Ubiquinone and other terpenoid-quinone biosynthesis pathway
INOH
PID NCI
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt Q64669
TrEMBL Q542Y0
UniProt Splice Variant
Entrez Gene 18104
UniGene Mm.407093
RefSeq NM_008706
OMIM
CCDS CCDS40465
HPRD
IMGT
MGI ID MGI:103187
MGI Symbol Nqo1
EMBL AK075568 CH466525 S75951 U12961
GenPept AAA80184 AAB32718 BAC35826 EDL11407
RNA Seq Atlas 18104

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca