InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Zfhx3

Summary

InnateDB Gene

IDBG-191004.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfhx3

Gene Name

zinc finger homeobox 3

Synonyms

A230102L03Rik; Atbf1; mKIAA4228; WBP9

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038872

Encoded Proteins

IDBP-191006

zinc finger homeobox 3

IDBP-789666

zinc finger homeobox 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140836:
This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:108703100-108961630

Strand

Forward strand

Band

Transcripts

ENSMUST00000043896	ENSMUSP00000044612
ENSMUST00000188994	ENSMUSP00000140025

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003779	actin binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0007010	cytoskeleton organization
GO:0007050	cell cycle arrest
GO:0007420	brain development
GO:0045662	negative regulation of myoblast differentiation
GO:0045663	positive regulation of myoblast differentiation
GO:0045664	regulation of neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000140836

View Gene Order

ENSBTAG00000014636

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

cmyb_pathway

C-MYB transcription factor network

Cross-References

SwissProt

TrEMBL

E9QMD3

UniProt Splice Variant

Entrez Gene

11906

UniGene

Mm.404045 Mm.416972 Mm.477670

RefSeq

NM_007496 XM_006530585 XM_006530586 XM_006531569

OMIM

CCDS

CCDS22651

HPRD

IMGT

MGI ID

MGI:99948

MGI Symbol

Zfhx3

EMBL

AC122873 AC127258 AC134561

GenPept

RNA Seq Atlas

11906