Version 5.4
Homo sapiens Gene: ARHGAP1
Summary
InnateDB Gene IDBG-41963.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP1
Gene Name Rho GTPase activating protein 1
Synonyms CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1
Species Homo sapiens
Ensembl Gene ENSG00000175220
Encoded Proteins
IDBP-41965
Rho GTPase activating protein 1
IDBP-601352
Rho GTPase activating protein 1
IDBP-602543
Rho GTPase activating protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:46677080-46700615
Strand Reverse strand
Band p11.2
Transcripts
ENST00000311956 ENSP00000310491
ENST00000526423
ENST00000528837 ENSP00000434883
ENST00000525488 ENSP00000432794
ENST00000527588
ENST00000529960
ENST00000524594
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0030675 Rac GTPase activator activity
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0009967 positive regulation of signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0043087 regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0001726 ruffle
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031252 cell leading edge
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027247
View Gene Order
ENSBTAG00000016501
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.138860
RefSeq NM_004308
HUGO
OMIM
CCDS CCDS7922
HPRD 04108
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca