Version 5.4
Mus musculus Gene: Vimp
Summary
InnateDB Gene IDBG-191630.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vimp
Gene Name VCP-interacting membrane protein
Synonyms 1500011E07Rik; C78786; H-4; H-47; H4; H47; Sels
Species Mus musculus
Ensembl Gene ENSMUSG00000075701
Encoded Proteins
IDBP-191632
histocompatibility 47
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3\' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:66079649-66089412
Strand Forward strand
Band C
Transcripts
ENSMUST00000101801 ENSMUSP00000099301
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008430 selenium binding
GO:0016209 antioxidant activity
GO:0019899 enzyme binding
Biological Process
GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus
GO:0006886 intracellular protein transport
GO:0006983 ER overload response
GO:0009749 response to glucose
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0030970 retrograde protein transport, ER to cytosol
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034599 cellular response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0050728 negative regulation of inflammatory response
GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process
GO:0051775 response to redox state
GO:0071222 cellular response to lipopolysaccharide
GO:0080164 regulation of nitric oxide metabolic process
GO:1902236 negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2000110 negative regulation of macrophage apoptotic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005881 cytoplasmic microtubule
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000131871
View Gene Order
ENSBTAG00000000640
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q9BCZ4
TrEMBL
UniProt Splice Variant
Entrez Gene 109815
UniGene Mm.482127
RefSeq NM_024439
OMIM
CCDS CCDS39977
HPRD
IMGT
MGI ID MGI:95994
MGI Symbol Vimp
EMBL AF335543 AK005204 BC011091
GenPept AAH11091 AAK07659 BAB23882
RNA Seq Atlas 109815

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca