InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: VIMP

Summary

InnateDB Gene

IDBG-628560.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VIMP

Gene Name

Selenoprotein S

Synonyms

SELS

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000640

Encoded Proteins

IDBP-679931

selenoprotein S

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131871:
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:5385098-5394275

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000842

ENSBTAP00000000842

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008430	selenium binding
GO:0016209	antioxidant activity
GO:0019899	enzyme binding

Biological Process

GO:0002865	negative regulation of acute inflammatory response to antigenic stimulus
GO:0006886	intracellular protein transport
GO:0006983	ER overload response
GO:0009749	response to glucose
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0030970	retrograde protein transport, ER to cytosol
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034599	cellular response to oxidative stress
GO:0045454	cell redox homeostasis
GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process
GO:0051775	response to redox state
GO:0071222	cellular response to lipopolysaccharide
GO:0080164	regulation of nitric oxide metabolic process
GO:1902236	negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2000110	negative regulation of macrophage apoptotic process

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005881	cytoplasmic microtubule
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0034361	very-low-density lipoprotein particle
GO:0034362	low-density lipoprotein particle

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000131871

View Gene Order

ENSMUSG00000075701

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04141

Protein processing in endoplasmic reticulum pathway

mmu04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

Q2KI76

TrEMBL

UniProt Splice Variant

Entrez Gene

512276

UniGene

RefSeq

NM_001046114 XM_005221722 XM_005221723

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC112740

GenPept

AAI12741

RNA Seq Atlas

512276