Version 5.4
Homo sapiens Gene: PTP4A2
Summary
InnateDB Gene IDBG-95523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTP4A2
Gene Name protein tyrosine phosphatase type IVA, member 2
Synonyms HH13; HH7-2; HU-PP-1; OV-1; PRL-2; PRL2; ptp-IV1a; ptp-IV1b; PTP4A; PTPCAAX2
Species Homo sapiens
Ensembl Gene ENSG00000184007
Encoded Proteins
IDBP-95525
protein tyrosine phosphatase type IVA, member 2
IDBP-378538
protein tyrosine phosphatase type IVA, member 2
IDBP-591410
protein tyrosine phosphatase type IVA, member 2
IDBP-600780
protein tyrosine phosphatase type IVA, member 2
IDBP-602203
protein tyrosine phosphatase type IVA, member 2
IDBP-584150
protein tyrosine phosphatase type IVA, member 2
IDBP-584327
protein tyrosine phosphatase type IVA, member 2
IDBP-807877
protein tyrosine phosphatase type IVA, member 2
IDBP-807883
protein tyrosine phosphatase type IVA, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:31906421-31944856
Strand Reverse strand
Band p35.2
Transcripts
ENST00000344035 ENSP00000344909
ENST00000457805 ENSP00000409260
ENST00000489313
ENST00000470404 ENSP00000435941
ENST00000484483
ENST00000468531 ENSP00000437251
ENST00000494444
ENST00000475464
ENST00000532001 ENSP00000433050
ENST00000528253 ENSP00000433800
ENST00000534796 ENSP00000433375
ENST00000532289
ENST00000526960
ENST00000524384
ENST00000528840
ENST00000529477
ENST00000533408
ENST00000602725 ENSP00000473259
ENST00000602683 ENSP00000473490
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0004727 prenylated protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028788
View Gene Order
ENSBTAG00000039121
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
prlsignalingeventspathway
Signaling events mediated by PRL
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.470477 Hs.713259
RefSeq NM_001195100 NM_001195101 NM_080391 XM_005271230 XM_005271231 XM_005271232
HUGO
OMIM
CCDS CCDS348 CCDS53292 CCDS59193
HPRD 03348
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca