Version 5.4
Mus musculus Gene: Mapk8ip1
Summary
InnateDB Gene IDBG-192264.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mapk8ip1
Gene Name mitogen-activated protein kinase 8 interacting protein 1
Synonyms IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip
Species Mus musculus
Ensembl Gene ENSMUSG00000027223
Encoded Proteins
IDBP-192266
mitogen-activated protein kinase 8 interacting protein 1
IDBP-258470
mitogen-activated protein kinase 8 interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121653:
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:92383676-92401263
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000050312 ENSMUSP00000050773
ENSMUST00000111279 ENSMUSP00000106910
ENSMUST00000149653
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005078 MAP-kinase scaffold activity
GO:0005515 protein binding
GO:0008432 JUN kinase binding
GO:0019894 kinesin binding
GO:0019901 protein kinase binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0042802 identical protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007258 JUN phosphorylation
GO:0009967 positive regulation of signal transduction
GO:0016192 vesicle-mediated transport
GO:0043066 negative regulation of apoptotic process
GO:0043508 negative regulation of JUN kinase activity
GO:0046328 regulation of JNK cascade
GO:0046329 negative regulation of JNK cascade
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0031966 mitochondrial membrane
GO:0043005 neuron projection
GO:0044294 dendritic growth cone
GO:0044295 axonal growth cone
GO:0044297 cell body
GO:0044302 dentate gyrus mossy fiber
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000121653
View Gene Order
ENSBTAG00000000317
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9WVI9
TrEMBL
UniProt Splice Variant
Entrez Gene 19099
UniGene Mm.2720 Mm.450831
RefSeq NM_001202445 NM_001202446 NM_011162
OMIM
CCDS CCDS57180 CCDS16446
HPRD
IMGT
MGI ID MGI:1309464
MGI Symbol Mapk8ip1
EMBL AF003115 AF054611 AF109768 AF109769 AF109770 AF109771 AF332075 AF332076
GenPept AAB66317 AAD22580 AAD38346 AAD38347 AAD38348 AAD38349 AAK56103 AAK56104
RNA Seq Atlas 19099

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca