Version 5.4
Bos taurus Gene: BT.105291
Summary
InnateDB Gene IDBG-637017.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.105291
Gene Name C-Jun-amino-terminal kinase-interacting protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000317
Encoded Proteins
IDBP-688999
C-Jun-amino-terminal kinase-interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121653:
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:76794436-76813776
Strand Forward strand
Band
Transcripts
ENSBTAT00000000419 ENSBTAP00000000419
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005078 MAP-kinase scaffold activity
GO:0005515 protein binding
GO:0019894 kinesin binding
GO:0019901 protein kinase binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007258 JUN phosphorylation
GO:0009967 positive regulation of signal transduction
GO:0016192 vesicle-mediated transport
GO:0046328 regulation of JNK cascade
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0043005 neuron projection
GO:0044297 cell body
GO:0044302 dentate gyrus mossy fiber
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000121653
View Gene Order
ENSMUSG00000027223
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BD27
UniProt Splice Variant
Entrez Gene 524806
UniGene Bt.32878
RefSeq NM_001102508 XM_005216462
HUGO HGNC:6882
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02041566
GenPept
RNA Seq Atlas 524806

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca