Version 5.4
Mus musculus Gene: Pik3c2b
Summary
InnateDB Gene IDBG-192493.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pik3c2b
Gene Name phosphoinositide-3-kinase, class 2, beta polypeptide
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026447
Encoded Proteins
IDBP-192495
phosphoinositide-3-kinase, class 2, beta polypeptide
IDBP-540443
phosphoinositide-3-kinase, class 2, beta polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133056:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:133045667-133108687
Strand Forward strand
Band E4
Transcripts
ENSMUST00000077730 ENSMUSP00000076911
ENSMUST00000153707 ENSMUSP00000115469
ENSMUST00000124934
ENSMUST00000145153
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001727 lipid kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0043491 protein kinase B signaling
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0030139 endocytic vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000133056
View Gene Order
ENSBTAG00000024633
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04070
Phosphatidylinositol signaling system pathway
mmu00562
Inositol phosphate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
PID NCI
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.359298 Mm.387308
RefSeq NM_001099276 XM_006529531 XM_006529532 XM_006529533
OMIM
CCDS CCDS48360
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca