InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PIK3C2B

Summary

InnateDB Gene

IDBG-628648.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIK3C2B

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000024633

Encoded Proteins

IDBP-680030

phosphoinositide-3-kinase, class 2, beta polypeptide

IDBP-680032

phosphoinositide-3-kinase, class 2, beta polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133056:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:1981479-2030002

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017388	ENSBTAP00000017388
ENSBTAT00000066140	ENSBTAP00000054386

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001727	lipid kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0016310	phosphorylation
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0043491	protein kinase B signaling
GO:0046854	phosphatidylinositol phosphorylation
GO:0048015	phosphatidylinositol-mediated signaling