Version 5.4
Mus musculus Gene: Ank2
Summary
InnateDB Gene IDBG-192780.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ank2
Gene Name ankyrin 2, brain
Synonyms AI835472; Ank-2; AW491075
Species Mus musculus
Ensembl Gene ENSMUSG00000032826
Encoded Proteins
IDBP-192782
ankyrin 2, brain
IDBP-790457
ankyrin 2, brain
IDBP-790460
ankyrin 2, brain
IDBP-790461
ankyrin 2, brain
IDBP-790463
ankyrin 2, brain
IDBP-790465
ankyrin 2, brain
IDBP-790466
ankyrin 2, brain
IDBP-790467
ankyrin 2, brain
IDBP-790468
ankyrin 2, brain
IDBP-790469
ankyrin 2, brain
IDBP-790470
ankyrin 2, brain
IDBP-790471
ankyrin 2, brain
IDBP-790472
ankyrin 2, brain
IDBP-790473
ankyrin 2, brain
IDBP-790474
ankyrin 2, brain
IDBP-790475
ankyrin 2, brain
IDBP-790476
ankyrin 2, brain
IDBP-790477
ankyrin 2, brain
IDBP-790478
ankyrin 2, brain
IDBP-790479
ankyrin 2, brain
IDBP-790480
ankyrin 2, brain
IDBP-790481
ankyrin 2, brain
IDBP-790482
ankyrin 2, brain
IDBP-790483
ankyrin 2, brain
IDBP-790484
ankyrin 2, brain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:126921606-127499259
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000044443 ENSMUSP00000043765
ENSMUST00000182704 ENSMUSP00000138492
ENSMUST00000182588 ENSMUSP00000138647
ENSMUST00000182078 ENSMUSP00000138753
ENSMUST00000182112 ENSMUSP00000138595
ENSMUST00000182726 ENSMUSP00000138545
ENSMUST00000182779 ENSMUSP00000138497
ENSMUST00000182064 ENSMUSP00000138620
ENSMUST00000182764 ENSMUSP00000138391
ENSMUST00000182977 ENSMUSP00000138574
ENSMUST00000182118 ENSMUSP00000138323
ENSMUST00000182571 ENSMUSP00000138747
ENSMUST00000182662 ENSMUSP00000138538
ENSMUST00000182594 ENSMUSP00000138202
ENSMUST00000182212
ENSMUST00000182271
ENSMUST00000182062 ENSMUSP00000138279
ENSMUST00000182025 ENSMUSP00000138157
ENSMUST00000183075
ENSMUST00000182959 ENSMUSP00000138251
ENSMUST00000182711 ENSMUSP00000138781
ENSMUST00000183097
ENSMUST00000182008 ENSMUSP00000138730
ENSMUST00000182547 ENSMUSP00000138602
ENSMUST00000182994 ENSMUSP00000138089
ENSMUST00000182610 ENSMUSP00000138231
ENSMUST00000182452 ENSMUSP00000138373
ENSMUST00000182050
ENSMUST00000183095 ENSMUSP00000138487
ENSMUST00000182876
ENSMUST00000183234
ENSMUST00000182316
ENSMUST00000189368 ENSMUSP00000140700
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030507 spectrin binding
GO:0030674 protein binding, bridging
GO:0044325 ion channel binding
GO:0051117 ATPase binding
Biological Process
GO:0002027 regulation of heart rate
GO:0003283 atrial septum development
GO:0006874 cellular calcium ion homeostasis
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0008104 protein localization
GO:0010628 positive regulation of gene expression
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0030913 paranodal junction assembly
GO:0031647 regulation of protein stability
GO:0033292 T-tubule organization
GO:0033365 protein localization to organelle
GO:0034394 protein localization to cell surface
GO:0034613 cellular protein localization
GO:0036309 protein localization to M-band
GO:0036371 protein localization to T-tubule
GO:0042981 regulation of apoptotic process
GO:0043268 positive regulation of potassium ion transport
GO:0050821 protein stabilization
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051597 response to methylmercury
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0055117 regulation of cardiac muscle contraction
GO:0060048 cardiac muscle contraction
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0070972 protein localization to endoplasmic reticulum
GO:0072659 protein localization to plasma membrane
GO:0072661 protein targeting to plasma membrane
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086014 atrial cardiac muscle cell action potential
GO:0086015 SA node cell action potential
GO:0086036 regulation of cardiac muscle cell membrane potential
GO:0086066 atrial cardiac muscle cell to AV node cell communication
GO:0086070 SA node cell to atrial cardiac muscle cell communication
GO:0086091 regulation of heart rate by cardiac conduction
GO:1901018 positive regulation of potassium ion transmembrane transporter activity
GO:1901019 regulation of calcium ion transmembrane transporter activity
GO:1901021 positive regulation of calcium ion transmembrane transporter activity
GO:2001257 regulation of cation channel activity
GO:2001259 positive regulation of cation channel activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0014704 intercalated disc
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0031430 M band
GO:0031672 A band
GO:0042383 sarcolemma
GO:0043005 neuron projection
GO:0043034 costamere
GO:0045121 membrane raft
GO:0045211 postsynaptic membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001034168 NM_178655 XM_006500879 XM_006500887 XM_006500888 XM_006500892 XM_006500894 XM_006500896 XM_006500897 XM_006500899 XM_006500900 XM_006500901 XM_006500902 XM_006500905
OMIM
CCDS CCDS38625
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca