InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACER1

Summary

InnateDB Gene

IDBG-643977.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACER1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008095

Encoded Proteins

IDBP-696583

alkaline ceramidase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167769:
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:19329860-19353051

Strand

Forward strand

Band

Transcripts

ENSBTAT00000010648

ENSBTAP00000010648

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017040	ceramidase activity
GO:0071633	dihydroceramidase activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006672	ceramide metabolic process
GO:0008544	epidermis development
GO:0010446	response to alkalinity
GO:0019216	regulation of lipid metabolic process
GO:0030148	sphingolipid biosynthetic process
GO:0030154	cell differentiation
GO:0030216	keratinocyte differentiation
GO:0046512	sphingosine biosynthetic process
GO:0046514	ceramide catabolic process
GO:0071277	cellular response to calcium ion