Version 5.4
Mus musculus Gene: Ythdf2
Summary
InnateDB Gene IDBG-193679.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ythdf2
Gene Name YTH domain family 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000040025
Encoded Proteins
IDBP-176661
YTH domain family 2
IDBP-540149
YTH domain family 2
IDBP-627269
YTH domain family 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198492:
This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:132184912-132212303
Strand Reverse strand
Band D2.3
Transcripts
ENSMUST00000085181 ENSMUSP00000082275
ENSMUST00000102570
ENSMUST00000152796 ENSMUSP00000120414
ENSMUST00000165072 ENSMUSP00000129225
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
GO:1990247 N6-methyladenosine-containing RNA binding
Biological Process
GO:0043488 regulation of mRNA stability
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198492
View Gene Order
ENSBTAG00000015771
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.23998 Mm.396485 Mm.460463
RefSeq NM_145393
OMIM
CCDS CCDS18719
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca