Version 5.4
Mus musculus Gene: Taf12
Summary
InnateDB Gene IDBG-193751.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Taf12
Gene Name TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor
Synonyms 20kDa; 2810422D08Rik; AW557038; Taf2J
Species Mus musculus
Ensembl Gene ENSMUSG00000028899
Encoded Proteins
IDBP-193753
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor
IDBP-269799
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120656:
Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:132274375-132295766
Strand Forward strand
Band D2.3
Transcripts
ENSMUST00000030731 ENSMUSP00000030731
ENSMUST00000105963 ENSMUSP00000101583
ENSMUST00000124365
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006352 DNA-templated transcription, initiation
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0043966 histone H3 acetylation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0000125 PCAF complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005669 transcription factor TFIID complex
GO:0030914 STAGA complex
GO:0033276 transcription factor TFTC complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120656
View Gene Order
ENSBTAG00000026660
Not yet available
Pathways
NETPATH
REACTOME
REACT_230204
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_218274
Chromatin organization pathway
REACT_244380
RNA Polymerase II Transcription Initiation pathway
REACT_255334
RNA Polymerase II Promoter Escape pathway
REACT_226917
HATs acetylate histones pathway
REACT_232708
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_255009
RNA Polymerase II Pre-transcription Events pathway
REACT_233572
Gene Expression pathway
REACT_242255
RNA Polymerase II Transcription pathway
KEGG
mmu03022
Basal transcription factors pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1655
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_2089
RNA Polymerase II Promoter Escape pathway
REACT_1851
RNA Polymerase II Transcription Initiation pathway
REACT_834
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_6332
HIV Transcription Initiation pathway
REACT_6253
RNA Polymerase II HIV Promoter Escape pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_172610
HATs acetylate histones pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_6256
HIV Life Cycle pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_6185
HIV Infection pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_209718
RNA Polymerase II Transcription pathway
REACT_205499
RNA Polymerase II Pre-transcription Events pathway
REACT_202835
RNA Polymerase II Promoter Escape pathway
REACT_226022
Gene Expression pathway
REACT_207632
Chromatin organization pathway
REACT_219482
HATs acetylate histones pathway
REACT_207660
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_208384
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_207656
RNA Polymerase II Transcription Initiation pathway
REACT_227044
Chromatin modifying enzymes pathway
KEGG
hsa03022
Basal transcription factors pathway
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
myc_pathway
C-MYC pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.331926 Mm.384453 Mm.400998
RefSeq NM_025579 XM_006539108 XM_006539109 XM_006539110
OMIM
CCDS CCDS18721
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca