Version 5.4
Homo sapiens Gene: EYA3
Summary
InnateDB Gene IDBG-95137.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EYA3
Gene Name eyes absent homolog 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158161
Encoded Proteins
IDBP-95139
eyes absent homolog 3 (Drosophila)
IDBP-95141
eyes absent homolog 3 (Drosophila)
IDBP-95143
eyes absent homolog 3 (Drosophila)
IDBP-362296
eyes absent homolog 3 (Drosophila)
IDBP-601729
eyes absent homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. A similar protein in mice acts as a transcriptional activator. [provided by RefSeq, Jul 2008]
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, where this gene is up-regulated via a micro-RNA that binds to the 3\' UTR of the transcript. A similar protein in mice acts as a transcriptional activator. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:27970344-28088696
Strand Reverse strand
Band p35.3
Transcripts
ENST00000373871 ENSP00000362978
ENST00000373864 ENSP00000362971
ENST00000373863 ENSP00000362970
ENST00000436342 ENSP00000405587
ENST00000495923
ENST00000471498
ENST00000468665
ENST00000540618 ENSP00000442558
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006302 double-strand break repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006470 protein dephosphorylation
GO:0007275 multicellular organismal development
GO:0007601 visual perception
GO:0009653 anatomical structure morphogenesis
GO:0010212 response to ionizing radiation
GO:0016576 histone dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0045739 positive regulation of DNA repair
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028886
View Gene Order
ENSBTAG00000043989
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.185774
RefSeq NM_001282560 NM_001282561 NM_001282562 NM_001990 XM_006710449 XM_006710450
HUGO
OMIM
CCDS CCDS316 CCDS60050 CCDS60051 CCDS60052
HPRD 09042
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca